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Intervertebral Disc Degeneration GLP-1 protects nucleus pulposus cells (NPCs) ( the primary cell type driving disc integrity) by inhibiting AP-1driven catabolic gene transcription (specifically BATF/JUN heterodimers that drive MMP13 and ADAMTS5), curtailing NF-B via SIRT1 upregulation, and differentially modulating STAT3 (suppressing pathological senescence in NPCs while promoting M2 macrophage polarization)

( 14 , 15 ) Many antioxidants work for 1 thing, or 2 things, or 3 things

Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

Weight changes are rarely dramatic and are often influenced by multiple factors, including diet, physical activity, and the underlying condition being treated